Severe Head Injury Brain Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Feasibility of brain biopsy
研究概览
简要总结
Safety and feasibility study investigating brain biopsy in severe head injury. When a patient undergoes craniotomy or ICP bolt insertion for trauma, a biopsy of brain tissue is taken.
Blood, saliva, urine and faeces samples are also taken for 7 days following the brain biopsy.
CSF is collected if a CSF drainage device is used.
详细描述
A minor amendment was submitted to allow histological and immunohistochemical analysis of the samples.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Severe traumatic brain injury -
排除标准
- •Coagulopathy
结局指标
主要结局
Feasibility of brain biopsy
时间窗: immediately after the intervention/procedure/surgery
Is it feasible to perform brain biopsy through ICP bolt or at time of craniotomy in TBI in order to obtain diagnostic tissue?
Safety of brain biopsy
时间窗: immediately after the intervention/procedure/surgery
Is it safe to perform brain biopsy through ICP bolt or at time of craniotomy in TBI?
次要结局
- Classification of TBI(immediately after the intervention/procedure/surgery)