ISRCTN76413758已完成未知
Magnetic Resonance Imaging using ultrasmall supermagnetic particles of iron oxide in patients under surveillance for abdominal aortic aneurysms to predict rupture or surgical repair
niversity of Edinburgh / NHS Lothian (UK)0 个研究点目标入组 342 人开始时间: 2013年3月4日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 342
研究概览
简要总结
- 2016 results in: https://www.ncbi.nlm.nih.gov/pubmed/27056256 2. 2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/28720724 3. 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29406857 (added 16/07/2019) 4. 2019 biomarker study results in (added 10/10/2019)
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •1. Abdominal aortic aneurysms measuring =40 mm in anteroposterior diameter on ultrasound scanning
- •2. Age =40 years. Patients with abdominal aortic aneurysms less than 40 years may have a connective tissue disorder and a different aetiology to their disease
排除标准
- •1. Patients expected to, or already received, imminent elective or emergency surgical or endovascular repair
- •2. Contraindication to magnetic resonance imaging scanning identified from magnetic resonance imaging safety questionnaire
- •3. Patients refusing or unable to give informed consent
- •4. Woman with child-bearing potential and who are breastfeeding will not be enrolled into the trial (woman who have experienced menarche, are pre-menopausal, have not been sterilised or who are currently pregnant)
- •5. Intercurrent illness including patients with a systemic inflammatory disorder or underlying malignancy (life expectancy < 2 years)
- •6. Renal dysfunction (eGFR =30 mL/min/1.73m2)
- •7. Polycythemia
- •8. Contraindication to ferumoxytol (evidence of known iron overload, hemochromatosis, known hypersensitivity to ferumoxytol or its components or anaemia not caused by iron deficiency)
- •9. Contraindication to Iodine
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