Evaluation of Efficacy of Antibacterial Activity of Licorice, Clove, and Chlorohexidine Mouthwashes on Salivary Streptococcus Mutans in a Group of Egyptian Children: Randomized Controlled Trial.
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Reduction of dental caries incidence in high-caries index pediatric patients using International Caries Detection and Assessment System.
研究概览
简要总结
A randomized controlled trial that compares the antibacterial effectiveness of three mouthwashes-licorice, clove, and chlorhexidine-in Egyptian children aged 7-12 years.
The main focus is Streptococcus mutans, one of the main bacteria associated with dental caries. The saliva samples will be collected from the children and the amount of S. mutans will be measured before and after using the assigned mouthwash.
The children will be randomly divided into groups, with each group receiving one of the three mouthwashes. The bacterial counts will then be compared to determine which mouthwash is most effective at reducing salivary S. mutans.
The research question is whether natural mouthwashes made from licorice or clove reduce the bacteria that cause cavities as effectively as chlorhexidine in children?
The study could help determine whether licorice and clove are effective natural alternatives or adjuncts to chlorhexidine, particularly considering that chlorhexidine can have undesirable effects with prolonged use.
Overall aim: Compare and evaluate the antibacterial efficacy of the three mouthwashes
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 7 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pediatric patients with high caries index based on CAMBRA.
- •Frankl scale 3 and 4 (cooperative).
排除标准
- •Patients with teeth showing signs of infection (abscess or fistula)
- •Patients with mucositis (can't be given alcohol containing mouthwashes)
- •Hypertensive patients.
- •Allergic patients.
- •Special health care patients.
研究组 & 干预措施
Chlorohexidine Mouthwash
干预措施: Mouth wash (Other)
Clove mouthwash
干预措施: Mouth wash (Other)
Licorice mouthwash
干预措施: Mouth wash (Other)
结局指标
主要结局
Reduction of dental caries incidence in high-caries index pediatric patients using International Caries Detection and Assessment System.
时间窗: Baseline(Day 1), 2 weeks postoperative, then 3 months postoperative.
次要结局
- Adverse events related to the use of the licorice and clove mouthwashes, regarding oral irritation and allergies using a questionnaire.(Through study completion, an average of 3 months.)
- The reduction in Streptococcus mutans count following the use of licorice and clove mouthwashes in Egyptian pediatric patients aged from 7 to 12.(Baseline(Day 1), 2 weeks postoperative, then 3 months postoperative.)
- Patient reported satisfaction, regarding the taste using a questionnaire.(Through study completion, an average of 3 months.)
研究者
PG NADINE
Primary investigator
British University In Egypt