a Prospective, Multicenter Cohort Study of Ischemic Cerebrovascular Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- Cerebrovascular events
研究概览
简要总结
This study aims to establish a multicenter, large-scale, prospective cohort of patients with ischemic stroke. Various biological samples such as blood, feces, and urine are collected to identify biomarkers associated with ischemic stroke. By integrating demographic information, clinical indicators, imaging parameters, and biomarker parameters, the study aims to develop risk assessment, early warning, and prognosis prediction models. Additionally, the study aims to identify key genes and explore relevant signaling pathways related to ischemic stroke.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of ischemic stroke.
- •Age ≥ 18 years.
- •Signed informed consent form.
排除标准
- •Patients with moderate to severe mental disorders or dementia who cannot cooperate to complete the informed consent and follow-up procedures.
- •Patients with neurological functional impairment caused by conditions such as migraine aura, epilepsy, or other non-ischemic strokes.
- •Agitated patients who cannot cooperate with imaging examinations.
- •Pregnant or lactating patients, as well as those planning to become pregnant within 90 days.
- •Patients with concurrent malignant tumors or severe systemic diseases with an expected survival period of less than 90 days.
- •Patients who have participated in other clinical studies within 30 days prior to enrollment or are currently participating in other interventional clinical studies.
结局指标
主要结局
Cerebrovascular events
时间窗: 3 months of onset in patients
Cerebrovascular events, including ischemic stroke, transient ischemic attack, cerebral hemorrhage, subarachnoid hemorrhage
mRS scores
时间窗: 3 months of onset in patients
Assessing patients' neurological functional impairment status using the mRS score
次要结局
未报告次要终点