Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- To measure time series of MRI imaging by the b-SSFP sequence.
研究概览
简要总结
In this study, the researchers investigate the feasibility of using rapid cine MR imaging to provide both offline and online soft-tissue-based image guidance. Such images will provide a significantly more complete picture of the spatial and temporal changes in thoracic anatomy. This more complete information will lay the groundwork for better radiotherapy planning and dose delivery in the presence of respiratory motion.
详细描述
Rapid MRI scans from Stage I-IV non-small-cell lung cancer (NSCLC) patients will be acquired. MR acquisition will be performed without extrinsically administered contrast, using a balanced turbo field echo (TFE) sequence and commercially available coils.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •AJCC Stage I, II, III or IV non-small-cell lung cancer to be treated using radiotherapy will be eligible for this study.
- •Any types and amounts of prior therapy will be allowed for this study.
- •Subjects must be greater than or equal to 18 years of age. There are no gender or ethnic restrictions.
- •Ability to understand and the willingness to sign a written informed consent document.
- •Able to tolerate supine position
- •ECOG performance status of 3 or less
排除标准
- •MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical devices e.g., cardiac pacemakers
- •Women who are pregnant or trying to get pregnant
- •Pain in supine position
结局指标
主要结局
To measure time series of MRI imaging by the b-SSFP sequence.
时间窗: 6 weeks
To use fast acquisition sequences to obtain 2D and 3D cine MR images of moving and deforming lung tumors. The signal to noise ration (SNR) and spatiotemporal resolution of imaging sequences will be optimized into a format potentially useful for radiotherapy guidance.
次要结局
未报告次要终点