Prevalence of Dental Dyschromia and Impact on the Quality of Life of Participants With Prolonged Hyperbilirubinemia During Their Early Years
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 120
- 试验地点
- 18
- 主要终点
- Prevalence of dental dyschromia
研究概览
简要总结
The main objective of this study is to assess the prevalence of dental discoloration (dental dyschromia) in children who experienced high levels of bilirubin in their blood (hyperbilirubinemia) during their early years. The study will also examine risk factors associated with this condition, such as the duration and severity of hyperbilirubinemia, underlying diseases, and treatments received.
The researchers hypothesize that the quality of life of individuals with dental dyschromia is lower than that of individuals without dyschromia. The results of this study will be used to discuss coverage for dental care with health insurance for children affected by this condition.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 12 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A patient with biliary atresia, progressive familial intrahepatic cholestasis, or Alagille syndrome
- •Patient or legal representative not opposed to participating in this research.
排除标准
- •Inability to understand and respond to quality of life questionnaires
结局指标
主要结局
Prevalence of dental dyschromia
时间窗: from birth to study completion, a maximum of 19 years
presence of dyschromia or not evaluated by 2 investigators
次要结局
- Presence or absence of dental dyschromia(through study completion, an average of 18 months)