Rehydration Efficiency During Ad-libitum Fluid Intake
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Cumulative urine output
研究概览
简要总结
It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin.
The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
盲法说明
non labeled bottles
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-60 years
- •Training at least 2 times per week
- •stable weight for the last 2 months (fluctuation less than 5 pounds)
排除标准
- •Night shifting work
- •Thyroid medication
- •Bariatric surgery
- •Cardiovascular disease
- •Renal disease
- •Hepatic disease
- •Participating in another study at the same time
- •Bodyweight over 110 pounds
研究组 & 干预措施
Water
Rehydration with low mineral content bottle water
干预措施: Plain Water (Other)
Carbohydrate Electrolyte solution
Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV
干预措施: Liquid IV Hydration Multiplier (Other)
Low Sugar electrolyte solution
10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV
干预措施: Liquid IV Sugar Free (Other)
结局指标
主要结局
Cumulative urine output
时间窗: during the first 4 hours of rehydration
Total amount of urine output during rehydration
Total fluid intake
时间窗: 4 hours of rehydration
Total amount of fluid ingested
Rate of absorption
时间窗: during the first 240 minutes of rehydration
The rate of Deuterium appearance in the blood during 240 minutes of rehydration
Net fluid balance
时间窗: at 3 hours of the rehydration period
amount of water retained during the rehydration period
Rate of absorption
时间窗: during the first 180 minutes of rehydration
The rate of Deuterium appearance in the blood during 180 minutes of rehydration
Cumulative urine output
时间窗: during the first 3 hours of rehydration
Total amount of urine output during rehydration
Net fluid balance
时间窗: at 4 hours of the rehydration period
amount of water retained during the rehydration period
Rate of absorption
时间窗: during the first 30 minutes of rehydration
The rate of Deuterium appearance in the blood during 30 minutes of rehydration
Rate of absorption
时间窗: during the first 60 minutes of rehydration
The rate of Deuterium appearance in the blood during 60 minutes of rehydration
Rate of absorption
时间窗: during the first 120 minutes of rehydration
The rate of Deuterium appearance in the blood during 120 minutes of rehydration
次要结局
- Plasma copeptin(at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period)
- Stomach fullness(at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period)
- Free Osmotic Clearance(at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period)
- Thirst(at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period)
- Free water Clearance(at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period)
- Plasma volume(at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period)
- Taste Likeness(at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period)
研究者
Stavros Kavouras
Professor & Assistant Dean
Arizona State University