Enhancing Innate Anti-Viral Resistance Through A Community-Based Intervention - Generation Xchange
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 160
- 试验地点
- 2
- 主要终点
- Concentration of Type I interferon antiviral activity (bioassay International Units / mL)
研究概览
简要总结
This randomized controlled trial will test whether a recently developed community-based intergenerational mentoring program known as Generation Xchange (GenX) can enhance antiviral resistance in older African-American women and men in a low-SES urban community. Additional studies will identify the biological processes that promote resistance to respiratory virus infections and viral disease in older African-American women and men.
详细描述
This randomized controlled intervention trial (planned n=160) will test whether participation in the Generation Xchange (GenX) intergenerational mentoring program can reduces vulnerability to respiratory virus infections (COVID, influenzas, colds), increase antiviral immune activity (Type I interferon responses), and reduce inflammatory immune activity in older African-American women and men living in a socioeconomically disadvantaged urban community. Blood samples will also be collected to determine which biological factors are most important in protecting older African-Americans from respiratory virus infection, and which of those factors is affected by the GenX intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
盲法说明
All data collected, assayed, coded, and analyzed by researchers blind to study condition and participant identity
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participating in the GenX intergenerational mentoring program
- •All GenX mentors > 50 years of age are eligible to participate in this research
- •GenX program participation requires:
- •Reside in neighborhood of GenX schools (South-Central Los Angeles)
- •Pass basic literacy and cognitive function tests
排除标准
- •Any health condition that would put participant at risk by enrollment/participation
研究组 & 干预措施
Delayed GenX
Participants engage in parallel training/educational activities, and subsequently commence GenX program activity after 3 months
干预措施: GenX intergenerational mentoring program (Behavioral)
Immediate GenX
Participants immediately commence GenX program activity (intergenerational mentoring)
干预措施: GenX intergenerational mentoring program (Behavioral)
结局指标
主要结局
Concentration of Type I interferon antiviral activity (bioassay International Units / mL)
时间窗: 10 months
Blood cell production of Type I interferon activity will stimulated by exposure to a fixed dose of model viral protein (TruCulture Resiquimod R848 tubes) and quantifying Type I interferon concentration in the cell culture supernatant fluid using the standard Armstrong bioassay (Armstrong, J.A. Cytopathic effect inhibition assay for interferon: microculture plate assay. Methods in enzymology 78, 381-387 (1981).) Antiviral activity is quantified as International Units of Interferon activity / mL.
次要结局
- Respiratory virus antibody concentration (WHO international units BAU/mL)(10 months)
- Pro-inflammatory cytokine concentration (pg/mL)(10 months)
研究者
Steve Cole, Ph.D.
Professor of Medicine and Psychiatry & Biobehavioral Sciences
University of California, Los Angeles