ISRCTN77943537已完成1 期
A fixed-sequence, drug-drug interaction study evaluating the effect of the cytochrome P450 3A inhibitor itraconazole on DNL343 in healthy participants
Denali Therapeutics (United States)0 个研究点目标入组 24 人开始时间: 2024年3月14日最近更新:
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Healthy male participants and healthy female participants of non-childbearing potential
- •2. Aged =18 to =55 years
- •3. Body mass index (BMI) of =18.5 to =30 kg/m²
- •4. Body weight of =50 kg
排除标准
- •1. History of clinically significant endocrine, pulmonary, cardiovascular, gastrointestinal, hepatic, pancreatic, renal, metabolic, hematologic, immunologic, or allergic disease, or other major disorders
- •2. History of malignancy, except fully resected basal cell carcinoma
- •3. History of clinically significant neurological or psychiatric diseases
- •4. History of serious adverse reaction or serious hypersensitivity to any drug, or history of allergy to any component of the DNL343 or itraconazole products
- •5. Are pregnant (ie, positive pregnancy test) or breastfeeding
研究者
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