â??Utilization of NIRS monitor to compare the regional cerebral oxygen saturation between dexmedetomidine and propofol sedation in mechanically ventilated critically ill patients with sepsis- A Prospective Randomized Control Trialâ??

All India Institute of Medical Sciences0 个研究点目标入组 0 人开始时间: 待定最近更新: 2022年2月21日

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•1) Adult patients (greater or equal to 18 years old) on mechanical ventilation, requiring sedation and satisfying the survival sepsis guidelines criteria for the diagnosis of sepsis.
•2)Patients expected to be on mechanical ventilation for atleast 48 hours from the time of screening for study enrollment.

•1)Mean arterial pressure less than 55mm Hg despite appropriate intravenous volume replacement and vasopressors.
•2)Patients in coma or with severe cognitive deficits due to structural brain diseases such as stroke, intracranial hemorrhage, cranial trauma, malignancy, anoxic brain injury, or cerebral edema.
•3)Benzodiazepine dependency or history of alcohol abuse based on the medical teamâ??s decision to institute a specific treatment plan involving benzodiazepines for this dependency.
•4)Active seizures during this ICU admission being treated with intravenous benzodiazepines.
•5)Inability to understand English/Hindi or deafness that will preclude delirium evaluation.
•6)Documented allergy to propofol or dexmedetomidine.
•7)Patients who are on muscle relaxant infusions at time of screening with plans to maintain paralysis greater than 48 hours.

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