Structure and Function of Retinal Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Quality of photoreceptor and retinal pigment epithelium (RPE) cell layers
研究概览
简要总结
Current clinical cameras do not allow clinicians to see the cells of the retina. This study will evaluate a new electronic camera's ability to observe the human retina in finer detail.
详细描述
This research study will (1) test the ability of a new electronic camera developed in Dr. Miller's laboratory to observe retina in human subjects, and (2) use the camera for observing disease in the eye. This new camera integrates cutting-edge technologies in adaptive optics (AO) and optical coherence tomography (OCT) that enable the camera to capture sharp images. The objective of our study is to find out (1) whether the AO-OCT camera will allow researchers to observe the retina with finer resolution than current clinical cameras, and (2) whether this finer detail is useful for observing the progression of disease in the eye.
To address the second objective, the study will subjects with various disease severity of drusen associated geographic atrophy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Device Feasibility
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Retinal disease of either inherited retinal degeneration or retinal toxicity
排除标准
- •Ocular media opacities
- •High refractive error
- •Pupil dilation imposes a risk to ocular health
研究组 & 干预措施
Retinal Disease
Subjects with either retinal toxicity or inherited retinal degeneration will undergo multimodal clinical imaging and Adaptive Optics Optical Coherence Tomography (AO-OCT) imaging at each study visit to document regions of disease and healthy retina over time.
干预措施: Adaptive Optics - Optical Coherence Tomography (AO-OCT) retinal imaging (Device)
结局指标
主要结局
Quality of photoreceptor and retinal pigment epithelium (RPE) cell layers
时间窗: 2 years
Images of the photoreceptor and RPE cell layers taken with clinical instruments and the AO-OCT will be compared.
Cone Photoreceptor Dysfunction
时间窗: 2 years
Images will be used to determine changes in cone photoreceptor dysfunction and death
RPE cell morphology changes
时间窗: 2 years
Images will be used to determine the changes in RPE cell morphology in regions of healthy and diseased retina (in subjects with retinal disease).
次要结局
未报告次要终点
研究者
Kristen Bowles Johnson
Post Doctoral Researcher
Indiana University