A Feasibility Study of a Pre-Conditioning Functional Resistance Training Programme in Older Adults With Probable Sarcopenia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 主要终点
- Recruitment rate, eligibility rate, randomisation acceptability, adherence, retention rate and acceptability
研究概览
简要总结
This study aims to assess whether a short, structured exercise programme is suitable and acceptable for older adults with early-stage muscle weakness (known as probable sarcopenia). Sarcopenia is a common condition associated with ageing that leads to reduced muscle strength, mobility, and independence, increasing the risk of falls, hospitalisation, and reduced quality of life.
Exercise, particularly resistance training, is recommended as the first-line treatment for sarcopenia. However, many programmes require participants to begin at relatively high levels of intensity, which may be challenging for individuals with low baseline strength or confidence. A short "pre-conditioning" phase of exercise may help prepare individuals physically and improve their ability to safely engage in more structured training in the future.
This study will investigate an 8-week functional resistance training (FRT) programme designed to improve movement ability, strength, and confidence using exercises that mimic everyday activities such as standing, stepping, and lifting. Participants will be randomly assigned to complete the same programme either in a supervised and clinic-based setting or independently and home-based setting following instruction and guidance.
The main aim of the study is to determine whether this type of programme is feasible and acceptable, including whether participants are willing to take part, attend sessions, and complete the programme safely. The study will also explore whether the programme may lead to improvements in physical function, strength, and quality of life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged ≥65 years
- •Confirmed at screening with probable sarcopenia according to EWGSOP2 criteria, defined as low muscle strength.
- •Community-dwelling,
- •Able to consent,
- •Able to demonstrate safe functional resistance training exercise technique assessed during pre-randomisation familiarisation session.
排除标准
- •Diagnosed with Sarcopenia or severe sarcopenia (EWGSOP2)
- •Previous history of myocardial infarction within 12 months
- •Terminal illness,
- •Unstable cardiovascular disease
- •Uncontrolled hypertension
- •Cognitive impairment affecting consent
- •Recent major surgery
- •Pre-planned surgery in the next 12 months
研究组 & 干预措施
8-week clinic-based pre-conditioning functional resistance exercise programme
干预措施: Pre-Conditioning Functional Resistance Exercise Program (Other)
8-week home-based pre-conditioning functional resistance exercise programme
干预措施: Pre-Conditioning Functional Resistance Exercise Program (Other)
结局指标
主要结局
Recruitment rate, eligibility rate, randomisation acceptability, adherence, retention rate and acceptability
时间窗: From enrolment to the end of treatment at 8 weeks
Recruitment rate, eligibility rate, randomisation acceptability, adherence, retention rate and acceptability of the exercise programme completed both in clinic, and at home.
次要结局
- Muscle mass via Bioelectrical Impedance Analysis(From enrolment until the end of the 8-week intervention period)
- Grip Strength with Hand Dynomometer(From enrolment until the end of the 8-week intervention period)
- Gait Speed over 4m(From enrolment until the end of the 8-week intervention period)
- EQ-5D-5L(From enrolment until the end of the 8-week intervention period)
- Short Physical Performance Battery(From enrolment until the end of the 8-week intervention period)
研究者
Thozhukat Sathyapalan
Professor of Endocrinology
University of Hull