临床试验/NCT00710255

NCT00710255已完成不适用

Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm Determined by Dynamic Analysis of Exhaled Breath Condensate.

University of Vermont1 个研究点分布在 1 个国家目标入组 8 人开始时间: 2007年10月最近更新: 2016年10月31日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University of Vermont
入组人数: 8
试验地点: 1
主要终点: Change in level of cystLTs and adenosine

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 12 Years 至 75 Years（Child, Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Physician diagnosed asthma
•Age 12-75 yrs
•FEV1 > 70% predicted
•HIB response > 10 %
•No smoking last 6 mo and < 10 pack yrs
•No URI last 4 weeks
•No asthma exacerbation last 4 weks
•Able to withhold SABA > 8 hrs and LABA > 24 hrs

排除标准

•Other lung disease
•Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers

结局指标

主要结局

Change in level of cystLTs and adenosine

时间窗: Before and after hyperpnea challenge

次要结局

Change in pH of EBC and change in pulmonary function(Before and after hyperpnea challenge)

研究者

发起方

University of Vermont

申办方类型

Other

责任方

Principal Investigator

主要研究者

David Kaminsky, MD

Professor

University of Vermont

研究点 (1)

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