Awareness and Attitudes Regarding Prenatal and Preimplantation Genetic Diagnosis for Inherited Breast/Ovarian Cancer Risk
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- To explore the attitudes of BRCA1/2 mutation carriers about PGD/PND, most notably benefits and drawbacks, as well as ethical and emotional considerations;
研究概览
简要总结
We are inviting you to participate in a study of how people who have had genetic counseling for breast/ovarian cancer risk feel about certain reproductive technologies, preimplantation genetic diagnosis (PGD) and prenatal genetic diagnosis (PND), that may reduce the chances of passing increased risk onto one's children. We would also like feedback from patients who have been to our clinic in the past on the best ways to talk about PGD and PND during genetic counseling sessions. We are seeking both the opinions of people who are interested in these technologies and those who are not. It does not matter whether you have heard of PGD or PND before - you can still participate. Your past experience with genetic counseling is valuable to us in deciding how to communicate this information during sessions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Females and males who are carriers of deleterious mutations in the genes BRCA1 or BRCA
- •Over age 18 and:
- •For women, less than 43
- •For men, less than
- •Received genetic testing and counseling for BRCA.
- •Fluent in English.
排除标准
- •Patients who are currently under treatment (chemotherapy, radiation)
- •Individuals who refuse to discuss reproductive issues.
- •Unable to give informed consent due to physical, cognitive, or psychiatric disability
结局指标
主要结局
To explore the attitudes of BRCA1/2 mutation carriers about PGD/PND, most notably benefits and drawbacks, as well as ethical and emotional considerations;
时间窗: conclusion of study
次要结局
- To elicit opinions from patients who have previously undergone BRCA1/2 genetic counseling as to when and how information about PGD/PND should be presented (e.g., timing, level of detail,etc)(conclusion of study)
- To explore whether different themes emerge for subgroups of patients (completed childbearing vs. not; affected vs. unaffected).(conclusion of study)
- To gain preliminary data on themes that might be particularly important to male BRCA1/2 carriers.(conclusion of study)