NCT02858414已完成不适用
Exploratory Study of Cellular Reservoirs in Blood From HIV Infected Patients: EURECA (ERANET to Unravel New Roads to Eradication and a Cure for AIDS) Study
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- Measure of the integrated viral reservoir size
研究概览
简要总结
This study evaluates the impact of highly active antiretroviral therapy on the size of the latent viral reservoirs in resting CD4+ T cells and monocytes in HIV positive patients. The activation state of the cells will be assessed, by measuring the activation of Akt, to determine its influence on the size of the viral reservoirs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HIV infected patients under Highly Active Anti-Retroviral Therapy (HAART) or Naïve from treatment
排除标准
- •Age limits
- •Pregnancy
- •Legal restrictions to consent
研究组 & 干预措施
blood sample
Experimental
干预措施: additional blood sample (Other)
结局指标
主要结局
Measure of the integrated viral reservoir size
时间窗: day 1
Measure by Alu-PCR. Results are given in number of integrated proviral DNA copies per 1 million cells.
Measure of the proviral reservoir size
时间窗: day 1
Measure by Total Proviral HIV DNA detection kit. Results are given in number of total proviral DNA copies per 1 million cells.
次要结局
- Measure of Akt activation(day 1)
研究者
研究点 (2)
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