Efficacy of Auricular Acupressure Combined With 0.1% Adapalene in the Treatment of Acne Vulgaris
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Change in Global Acne Grading System (GAGS) score
研究概览
简要总结
Acne vulgaris is a common chronic inflammatory skin condition that can significantly affect quality of life. Standard treatments such as topical retinoids are effective but may not fully control symptoms in all patients.
This study evaluated the effectiveness of auricular acupressure combined with topical 0.1% adapalene compared with topical 0.1% adapalene alone in patients with acne vulgaris. Auricular acupressure is a non-invasive traditional medicine technique that may help regulate inflammatory responses and improve skin conditions.
The objective of this study was to determine whether the combination therapy provides greater improvement in acne severity and clinical outcomes than standard topical treatment alone.
详细描述
Acne vulgaris is a multifactorial inflammatory skin disease commonly affecting adolescents and young adults. Although topical retinoids such as adapalene are widely used and effective, some patients experience incomplete responses or persistent symptoms.
Auricular acupressure is a traditional therapeutic method that involves stimulating specific points on the ear and has been used to support systemic regulation and inflammatory control. This study was designed to explore the potential added benefit of auricular acupressure when combined with standard topical adapalene therapy.
This interventional study compared two treatment approaches in patients with acne vulgaris: auricular acupressure combined with topical 0.1% adapalene versus topical 0.1% adapalene alone. Participants were assigned to treatment groups according to the study protocol and followed for clinical assessment.
The primary objective of the study was to evaluate the effectiveness of the combination therapy in improving acne severity and overall clinical outcomes compared with standard treatment alone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female patients aged 18 to 35 years.
- •Clinical diagnosis of mild to moderate acne vulgaris based on the Global Acne Grading System (GAGS).
- •Willingness to comply with the study protocol and attend all scheduled visits.
- •Provided written informed consent prior to participation.
排除标准
- •Severe acne vulgaris requiring systemic treatment.
- •Use of systemic acne treatments (such as isotretinoin, antibiotics, or hormonal therapy) within the past 4 weeks.
- •Use of topical acne treatments within 2 weeks prior to enrollment.
- •Presence of other dermatological conditions that may interfere with evaluation.
- •Pregnancy or breastfeeding.
- •Known allergy or hypersensitivity to adapalene or components of the intervention.
研究组 & 干预措施
Auricular Acupressure Plus Adapalene
Participants received auricular acupressure combined with topical 0.1% adapalene.
干预措施: Auricular Acupressure (Other)
Auricular Acupressure Plus Adapalene
Participants received auricular acupressure combined with topical 0.1% adapalene.
干预措施: Adapalene 0.1% Gel (Drug)
Active Comparator
Participants received topical 0.1% adapalene alone.
干预措施: Adapalene 0.1% Gel (Drug)
结局指标
主要结局
Change in Global Acne Grading System (GAGS) score
时间窗: From baseline to week 4
The Global Acne Grading System (GAGS) was used to assess acne severity. The total GAGS score was calculated at baseline and at the end of treatment. The primary outcome was the change in GAGS score from baseline to the end of treatment, and comparisons were made between the two study groups.
次要结局
- Change in inflammatory and non-inflammatory acne lesion counts(From baseline to week 4)
- Change in Dermatology Life Quality Index (DLQI) score(From baseline to week 4)
- Incidence of treatment-related adverse events(During the 4-week treatment period)
研究者
Trang Le Thi Ha
Medical Doctor
University of Medicine and Pharmacy at Ho Chi Minh City