Hypercalcemia After Cosmetic Paraffin Oil Injections: Unravelling Etiology, Pathogenesis and Potential Treatments
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Number of patients with concentration of ionized calcium in plasma above normal range = Hypercalcemia
研究概览
简要总结
The aim of the study is to characterize paraffin oil induced granulomatous disease. We will investigate pathogenesis and natural history of paraffin disease. Subsequently, through further translational studies, we intend to identify novel treatments to be tested in future randomized clinical trials.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •previous intramuscular injection of paraffin or other oil
排除标准
- 未提供
结局指标
主要结局
Number of patients with concentration of ionized calcium in plasma above normal range = Hypercalcemia
时间窗: at first examination or developed during observation period until 2025
Hypercalcemia in plasma (exploratory not intervention study). yes or no and level.
Number of patients with concentration of parathyroid hormone PTH in plasma below normal range
时间窗: at first examination or developed during observation period until 2025
PTH level in plasma indicator of hypercalcemia
次要结局
未报告次要终点
研究者
Ebbe Eldrup, MD, DMSc
Principal investigator Consultant Endocrinologist MD DMSc
Herlev Hospital