Letrozole Plus Misoprostol Versus Misoprostol Only in Induction of Missed Abortion: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400
- 试验地点
- 1
研究概览
简要总结
This study aimed to evaluate the effect of letrozole plus misoprostol to terminate non-viable pregnancies in first trimester compared with the use of misoprostol alone.
详细描述
Inducing abortion by drugs is an alternative for surgery intervention, which has economic benefits with lower side effects and its rate of success is 60 to 95%.
Letrozole is also one of aromatase inhibitors, which is used to stimulate ovulation in infertile women suffering ovulatory dysfunction. This drug is one of the main drugs for inhibiting aromatase, with a relatively short 45-hour half life, which is active orally and inhibits aromatase enzyme reversibly.
Misoprostol is a relatively safe drug and of its side effects it is possible to mention to gestational effects, feeling of warmth, and shivering. Severe side effects of misoprostol consumption are severe bleeding and endometritis, with less than 1% prevalence based on studies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age from 18 to 45 years.
- •Women with nonviable pregnancies undergoing 1st-trimester abortion.
排除标准
- •Medical diseases like renal or liver disease.
- •Severe bleeding and shocked patients.
- •Inevitable abortion.
- •Hypersensitivity to any of the drugs.
研究者
Rania Mahmoud Ahmed Elkhalily
Lecturer of Obstetrics and Gynecology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Sohag University