Effects of a Telerehabilitation Program and Detraining on Cardiorespiratory Fitness in Patients With Post-COVID-19 Sequelae
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 130
- 试验地点
- 2
- 主要终点
- Mechanical efficiency
研究概览
简要总结
The primary objective of this study is to evaluate the effects of a 15-week home telerehabilitation program and a detraining period on cardiorespiratory fitness and muscular efficiency in patients with post-COVID-19 sequelae compared to a control group of COVID-19 patients. We hypothesize that cardiorespiratory fitness and muscular efficiency significantly improve in patients who carry out the home telerehabilitation program. However, the cardiorespiratory and muscular adaptations achieved and tolerance to exercise are lost over time as an effect of detraining.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18 years
- •molecular diagnosis (reverse transcription polymerase chain reaction [RT-PCR]) of infection by SARS-CoV-2
- •post-COVID-19 symptomatology
排除标准
- •severe neurological disease
- •active oncological disease
- •neuromuscular disease and/or orthopedic disorders impeding normal development of cardiopulmonary exercise test
- •the absence of signed informed consent
结局指标
主要结局
Mechanical efficiency
时间窗: 1 week per group
Delta efficiency in percentage
Cardiorespiratory fitness: relative oxygen uptake
时间窗: 1 week per group
relative peak oxygen uptake in L/min
Ventilatory efficiency
时间窗: 1 week per group
VE/VCO2 slope
Exercise capacity during cardiopulmonary exercise test
时间窗: 1 week per group
Exercise time in minutes and seconds
Cardiorespiratory fitness: absolute oxygen uptake
时间窗: 1 week per group
absolute peak oxygen uptake in L/min
Power output during pedaling
时间窗: 1 week per group
Power output in watts
次要结局
- Respiratory exchange ratio(1 week per group)
- ventilatory equivalent for carbon dioxide(1 week per group)
- End-tidal partial pressure of oxygen(1 week per group)
- Minute ventilation(1 week per group)
- ventilatory equivalent for oxygen(1 week per group)
- end-tidal partial pressure of carbon dioxide(1 week per group)
- Weight of COVID-19 patients(1 week per group)
- Height of COVID-19 patients(1 week per group)
- Body mass index of COVID-19 patients(1 week per group)
研究者
Manuel Vicente Garnacho Castano
Coordinator of the DAFNiS research group
Campus docent Sant Joan de Déu-Universitat de Barcelona