Computed Tomography Angiography Accuracy in Brain Death Diagnosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 106
- 试验地点
- 1
- 主要终点
- Assess the presence or absence of contrast medium filling of the intracranial vessels in comatose patients.
研究概览
简要总结
The purpose of this study is to assess the reliability of computed tomography angiography (CTA) to diagnose brain death, face of several conditions that make impossible to define such diagnosis using clinical criteria exclusively.
详细描述
Critically ill patients, presenting Glasgow Coma Score 5 or lower, will be submitted to the Computed Tomography Angiography (CTA) of the skull assessment, and follow a clinical evaluation for brain death, additionally, transcranial Doppler would be applied as the gold standard for brain death.
We will exclude patients whose do not can be submitted to contrast injection, or if a brain death clinical evaluation has been performed prior the CTA.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals of any age or sex with brain death suspicion raised, before clinical test.
- •Comatose patients presenting Glasgow Coma Score as or under 5 points, under sedative agents or not.
排除标准
- •Brain dead patients clinically confirmed.
- •Contraindications to the use of contrast medium (renal failure or allergy).
结局指标
主要结局
Assess the presence or absence of contrast medium filling of the intracranial vessels in comatose patients.
时间窗: 1 year
After excluding confounding factors, we will submit comatose patients to CTA. Immediately after the exam, we will perform clinical evaluation for brain death and calculate CTA sensibility and specificity for this diagnosis. Time between these two interventions will be measured.
次要结局
未报告次要终点
研究者
Sergio Brasil, MD MSc
MD
University of Sao Paulo