Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Paced Auditory Serial Addition Test (PASAT)
研究概览
简要总结
Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise has been shown to improve memory and thinking in persons with diseases such as Alzheimer's. This study will investigate whether a program of aerobic exercise can improve memory and thinking in persons with MS
详细描述
Persons with Multiple Sclerosis(MS)will be screened for eligibility and randomized to a protocol with two intervention arms. One group will have aerobic training on a recumbent cross trainer three times a week for 20-30 minutes/session. The other group will participate in stretching exercises at the same frequency and intensity.Total training time will be six months.Outcome measures will include tests of memory and thinking, and fitness measures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical Diagnosis of MS Complaints of cognitive problems Able to ride a recumbent cross trainer
排除标准
- •Cardiopulmonary or structural disease that would limit ability to participate in exercise training On treatment with chemotherapy or natalizumab Screening score of >50 on PASAT
研究组 & 干预措施
aerobic exercise
Subjects will train on a recumbent cross trainer 20-30 minutes/session for three times/week for six months under supervision of a fitness specialist
干预措施: exercise (Behavioral)
stretching
Subjects will particiate in supervised stretching at same frauency, duration and intensity of aerobic exericse arm
干预措施: stretching (Behavioral)
结局指标
主要结局
Paced Auditory Serial Addition Test (PASAT)
时间窗: 36 weeks
test of attention and information processing
次要结局
- Symbol Digit Modalities Test (SDMT)(36 weeks)
- VO2 max(36 weeks)
- Long latency cognitive event related potentials ( LLCERP)(36 weeks)
研究者
Barbara Giesser
Clincial Profesor of Neurology
University of California, Los Angeles