NCT01757990已完成2 期
A Comparative Clinical Evaluation of the Effect of Stevia Rebaudiana Extracts and Sucrose on Dental Plaque pH (Stephan Curve Trend) Using a Microtouch Electrode in Healthy Volunteers. A Phase II Study.
Università degli Studi di Sassari0 个研究点目标入组 20 人开始时间: 2012年3月1日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 主要终点
- Plaque-pH modification
研究概览
简要总结
The aim of the present investigation was to evaluate the effect of stevioside and rebaudioside on several variables related to caries development. Two approaches were performed: an in vitro evaluation of the growth of a culture of mutans streptococci and in vivo randomized study on the effect of a single rinse containing stevioside and rebaudioside on plaque-pH.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •good general health, normal salivary secretion rate, normal buffer capacity
排除标准
- •systemic diseases, salivary secretion reduction, reduced buffer capacity
结局指标
主要结局
Plaque-pH modification
时间窗: 5, 10, 15, 30, 45, 60 minutes
Plaque pH was measured at baseline and 5, 10, 15, 30, 45 and 60 minutes after each mouth rinse
次要结局
未报告次要终点
研究者
Guglielmo Campus
Associate Professor of Community Dentistry
Università degli Studi di Sassari
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