Impact of opioids on heart rate during rapid sequence intubation : Double-blind randomized controlled study (CANDY-CRASH).

Centre Hospitalier Sud Francilien0 个研究点目标入组 150 人开始时间: 2022年8月1日最近更新: 2024年8月21日

适应症

试验速览

Summary

•Patient over 65 years old and any possible ASA OR Patient aged 55 to 65 years old with an ASA = 3, Patient undergoing surgery (urgent or scheduled), requiring general anesthesia in rapid sequence, because considered to have a full stomach, i.e. with: gastro-oesophageal pathology or gastroparesis or a history of bariatric surgery or occlusive syndrome (with or without naso-gastric tube), or failure to respect food <6 hours and/or water <2 hours, Patient regardless of body mass index (BMI), Patient regardless of their orotracheal intubation criteria present during the anesthesia consultation, Patient informed of the study who gave their written consent before starting the study procedures, Patient affiliated to a French social security system

•Patient < 55 years old, Patient participating in another interventional clinical research, Patient under AME (State Medical Aid), Patient on beta blockers, Atrial fibrillation or other rhythm or conduction disturbances, Patient in hemodynamic failure SBP < 90 mmHg and DBP < 60 mmHg) and/or on catecholamines before the start of GA, Patient having a history of stroke, hemorrhagic and/or ischemic and/or transient, Combination with opioid agonists-antagonists or partial opioid antagonists, Known hypersensitivity to one of the study drugs or to opioids, History of difficult intubation, Patient under guardianship, curatorship or deprived of liberty

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