Enhancing Speech Fluency With Non-invasive Brain Stimulation in Developmental Stuttering
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change from baseline proportion of stuttering in speech sample
研究概览
简要总结
This study aims to test whether the addition of transcranial direct current stimulation (TDCS) to speech fluency training results in improvements in speech fluency in adults with developmental stuttering. Half of the participants will receive anodal TDCS on five consecutive days, the other half will receive a sham stimulation for the same amount of time.
详细描述
Studies using TDCS have shown improvements in motor performance, and in expressive language skills in clinical and healthy populations. The benefits of single sessions of TDCS are short-lived. However, stimulation over multiple sessions can increase and prolong learning effects that can persist for several weeks after the end of the stimulation period. We aim to target left hemisphere frontal regions involved in speech production with TDCS, and to pair this stimulation with speech fluency training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Native speaker of English.
- •Right handed.
- •Participant has moderate to severe Developmental Stuttering (Stammering)
排除标准
- •Speech, language or communication disorder other than Developmental Stuttering.
- •Sensory impairment (hearing loss or visual impairment)
- •History of drug abuse.
- •History of seizures
- •History of a neurological or psychiatric illness.
- •History of neurosurgical procedure.
- •Currently taking certain prescription medications such as anti-depressants and anti-malarial medication (as these may lower the seizure threshold)
结局指标
主要结局
Change from baseline proportion of stuttering in speech sample
时间窗: 6 weeks post-treatment
Quantitative measurement of stuttering
次要结局
- Change from baseline on the Stuttering Severity Instrument version 4 (SSI-4)(6 weeks post-treatment)
- Change from baseline on Overall Assessment of Speaker's Experience of Stuttering (OASES)(6 weeks post-treatment)