Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 155
- 试验地点
- 2
- 主要终点
- median SRT (simple reaction time) to a stimulus (in milliseconds)
研究概览
简要总结
In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 40 and 85
- •French mother tongue
- •Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
- •MCI, according to Albert et al.'s criteria (Albert et al., 2011)
- •Mild dementia (MMSE>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
- •Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
- •Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
- •Social security coverage
- •Healthy controls
- •Healthy age and gender matched volunteers will be recruited into the study from the general population.
排除标准
- •Reading or writing difficulties related to a learning disorder or illiteracy.
- •A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):
- •NYHA stage IV dyspnoea.
- •respiratory impairment requiring oxygen therapy.
- •liver impairment.
- •kidney failure, progressing neoplastic disease, or past or present alcohol abuse.
- •Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:
- •meningitis or encephalitis.
- •severe head injury.
- •sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).
- •epilepsy (requiring ongoing treatment),
- •psychiatric disorders (other than treated depression).
- •treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state.
- •Impossibility to perform a neuropsychological evaluation or brain MRI.
- •Withdrawal from the study at any time, if desired.
- •Pregnancy
- •Contra-indication to MRI:
- •nerve stimulators
- •cochlear implants
- •ferromagnetic foreign bodies close to nervous structures in the eye or brain
- •cerebral shunts
- •dental appliances
- •Legal guardianship or incarceration.
研究组 & 干预措施
Alzheimer disease
Alzheimer disease patients Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation
干预措施: Brain MRI (Device)
Alzheimer disease
Alzheimer disease patients Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation
干预措施: neuropsychological evaluation (Other)
Alzheimer disease
Alzheimer disease patients Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation
干预措施: Blood (Biological)
control
Healthy age- and gender-matched volunteers will be recruited into the study from the general population.
Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation
干预措施: Brain MRI (Device)
control
Healthy age- and gender-matched volunteers will be recruited into the study from the general population.
Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation
干预措施: neuropsychological evaluation (Other)
control
Healthy age- and gender-matched volunteers will be recruited into the study from the general population.
Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation
干预措施: Blood (Biological)
结局指标
主要结局
median SRT (simple reaction time) to a stimulus (in milliseconds)
时间窗: Day 0
次要结局
未报告次要终点