BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders (B-GLAD)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Change in Signal Intensity
研究概览
简要总结
This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.
详细描述
The investigators will prospectively analyze OS-CMR data from patients with a generalized anxiety disorder from one site. The investigators will observe how an anxiety disorder affects the OS-CMR data. In a follow-up MRI scan, the investigators will look at the OS-CMR of a subgroup who have anxiety disorder and are also undertaking cognitive behavioural therapy to asses how and if this therapy affects the OS-CMR data.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient population:
- •Confirmation of an anxiety disorder as identified by the PSWQ,
- •No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system (except anxiety and depression)
- •Non-smoker
- •Healthy Volunteers:
- •Age 18-55
- •No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system
- •Non-smoker
排除标准
- •General MRI contraindications: pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, pregnancy
- •History of significant neurological disease or illness that is not anxiety (e.g. Dementia, stroke)
- •Hemodynamically unstable conditions
- •Significant or uncontrolled arrhythmias
- •Severe pulmonary disease
- •Recent (<90 days) myocardial infarction
- •Recent (<90 days) surgery or coronary intervention
- •Consumption of caffeine (caffeinated beverages, coffee, tea, cocoa, chocolate) within 12h of the exam
- •Use of benzodiazepines or other short-acting anxiety medications (<1 day)
结局指标
主要结局
Change in Signal Intensity
时间窗: Baseline
Change in signal intensity between the baseline signal intensity and the signal intensity at 30 seconds of breath hold
次要结局
未报告次要终点
研究者
Matthias Friedrich
Principal Investigator
McGill University Health Centre/Research Institute of the McGill University Health Centre