Comparison of Effectiveness in Patients of Gastroesophageal Reflux Disease Taking Esomeprazole Versus Vonoprazan.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 824
- 试验地点
- 1
- 主要终点
- Sufficient relief
研究概览
简要总结
Local literature is deprived of data comparing the effectiveness of esomeprazole and vonoprazan in patients with gastroesophageal reflux disease (GERD). This study was planned with the objective of comparing the effectiveness of esomeprazole versus vonoprazan in patients diagnosed with GERD.
详细描述
Addressing the pressing need for an in-depth understanding and comparison of treatment options for the escalating prevalence of GERD, a condition significantly impacting patients' quality of life, is crucial. The study's results would not only provide local data, but also help doctors choose between esomeprazole and vonoprazan as the best treatment option. This would improve patient care and help doctors make better decisions, which would ultimately lead to better management of GERD and the overall health of patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any gender
- •Aged 18 to 65 years
- •Presenting with GERD
排除标准
- •Patients with hepatic, renal, respiratory, or cardiac disease accessed on history and medical records.
- •Any previous history of malignancy accessed from medical records.
- •Pregnancy and Lactation
- •Currently using histamine-2 receptor antagonists, antacids, gastrointestinal motility stimulants, and steroids.
- •History of drug allergy to proton pump Inhibitors (PPIs).
研究组 & 干预措施
Group-A
Patients received a once-daily dose of 20 mg of esomeprazole after the evening meal for 4 weeks.
干预措施: Esomeprazole (Drug)
Group-B
Patients received a once-daily dose of 20 mg of vonoprazan after the evening meal for 4 weeks.
干预措施: Vonoprazan (Drug)
结局指标
主要结局
Sufficient relief
时间窗: 4 weeks
The frequency of patients who achieved sufficient relief was noted.
次要结局
未报告次要终点
研究者
Muhammad Aamir Latif
Research Consultant
RESnTEC, Institute of Research