Heparin-binding Protein and Heparins
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Changes in the level of Heparin-binding protein
研究概览
简要总结
Heparin-Binding protein is a protein from primary and secretory granluae of white blood cells. It is released when white blood cells become activated and has been advocated as a biomarker for sepsis. The aim of this study is to find out if Heparins in clinical doses can change the level of Heparin-binding protein in plasma.
详细描述
Blood samples are taken from patients before and after Heparins in clinical doses. The effects of heparins on Heparin-binding protein concentration in plasma is measured. This is a small observational study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Planned endovascular treatment of aortic aneurysm or peripheral vascular surgery where unfractionated heparin in >3000 units are given perioperatively
- •Planned subcutaneous low molecular weight heparin as a thromboprophylactic treatment after major surgery or on Intensive Care treated patients.
- •Planned open heart surgery with cardiopulmonary bypass.
排除标准
- •Under 18 years
- •Unable to get informed consent from patient or relative
结局指标
主要结局
Changes in the level of Heparin-binding protein
时间窗: Repeated blood sampling during minimum of 1 hour and maximum of 5 hours after given heparin
Blood samples are taken before and after given heparin
次要结局
未报告次要终点
研究者
Halla Halldorsdottir
MD
Karolinska University Hospital