NCT00782938已完成不适用
Serum Anticholinergic Activity (SAA) and BIS-EEG as Potential Markers for Cognitive Ability and/or the Anticholinergic Medication in ACVB Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Cognitive dysfunction measured by neurocognitive test battery
研究概览
简要总结
Drugs with anticholinergic potential increase the risk of postoperative transient and persistent cognitive dysfunction especially in cardiac patients. The investigators main goal is to identify preoperative risk factors and to monitor postoperative patients' state in relation to SAA activity and bilateral BIS-EEG changes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •written compliance to the study participation
- •a good knowledge in German speech
- •no red/ green blindness
- •no previous neurological and/or psychiatric illness
- •good ability to see and to hear
- •Mini-Mental-State-Examination (MMSE) better than 25 points
排除标准
- •no written compliance to the study participation
- •bad knowledge in German speech
- •red/ green blindness
- •previous neurological and/or psychiatric illness
- •no ability to see and to hear
- •Mini-Mental-State-Examination (MMSE) lower than 25 points
结局指标
主要结局
Cognitive dysfunction measured by neurocognitive test battery
时间窗: 3 month postsurgery
次要结局
- SAA, BIS-EEG, descriptive patients' characteristics(24 h postsurgery)
研究者
研究点 (1)
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