RBR-8jyhxh已完成2 期
Randomized clinical trial for the treatment of moderate to severe cases of COVID-19 with Chloroquine and Colchicine
Hospital das Clínicas de Ribeirão Preto0 个研究点开始时间: 2020年7月30日最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
研究概览
简要总结
Patients who received colchicine in this randomised, double-blinded, placebo-controlled clinical trial presented better evolution in terms of the need for supplemental oxygen and the length of hospitalisation. Serum CRP was a laboratory marker of clinical improvement. Colchicine was safe and well tolerated.
研究设计
- 研究类型
- Intervention
入排标准
- 年龄范围
- 18Y 至 0（—）
入选标准
- •Moderate or severe forms of COVID-19; 18 years or older; body weight of 50 kg or more; serum Ca2+ and K+ normal; QT interval lower than 450 ms at 12 derivations electrocardiogram; beta-HCG (serum or urine) negative (if woman under 50).
排除标准
- •Mild and critical forms of COVID-19; allergy to any of the medications under study; diagnosis of porphyria, myasthenia gravis or uncontrolled arrhythmia at admission; pregnancy; use of digoxin, amiodarone, verapamil or metoprolol; use of protease inhibitors; history of chronic liver disease with liver dysfunction; unable to understand the information contained in the Consent Form.
研究者
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