NCT01204086Unknown4 期
Pharmacogenomics Studies of Antidepressants
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Hamilton Depression Rating Scale (HDRS)
研究概览
简要总结
The purpose of this study is to establish the clinical effectiveness of antidepressants by pharmacogenomic approach, and to determine the levels of inflammatory factors between the baseline and the end point of the study in Taiwanese major depressive disorder (MDD) patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 16-65 years old
- •Signed informed consent by patient or legal representative
- •Hamilton Rating Scale for Depression (HDRS) scores ≥ 16
- •A diagnosis of MDD according to DSM-IV criteria made by a specialist in psychiatry
排除标准
- •monoamine oxidase inhibitor or antidepressant treatment within two weeks prior to entering the study
- •A DSM-IV diagnosis of substance abuse within the past three months
- •An organic mental disease, mental retardation or dementia
- •A serious surgical condition or physical illness
- •Patients who were pregnant or breastfeeding
研究组 & 干预措施
venlafaxine
Experimental
干预措施: Venlafaxine (Drug)
fluoxetine
Experimental
干预措施: Fluoxetine (Drug)
结局指标
主要结局
Hamilton Depression Rating Scale (HDRS)
时间窗: 6 weeks
次要结局
- C-reactive Protein and IL-6(6 weeks)
- fasting blood glucose, lipid profiles(6 weeks)
研究者
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
Pharmacogenomic Study to Predict Antidepressant Responsiveness in Depressed PatientsAdverse Reaction to DrugDepressionNCT00817375Samsung Medical Center1,000
撤回
不适用
Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision SupportDepressionNCT03952494Weill Medical College of Cornell University
已完成
不适用
Clinical Pharmacogenomics of Antidepressant ResponseDepressionNCT00384020National Health Research Institutes, Taiwan402
Unknown
不适用
Predict Antidepressant Responsiveness Using PharmacogenomicsDepressive SymptomsDepressionNCT01228357Samsung Medical Center1,000
Unknown
不适用
Development of Pharmacogenomic Method to Predict Antidepressant ResponsivenessAntidepressant Drug Adverse ReactionDepressionNCT00817011Samsung Medical Center1,000