Genetic Basis of Hemangiomas
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- SNP
研究概览
简要总结
The purpose of this study is to determine if there are genes that are common in children with infantile hemangioma. This information will allow physicians to improve care for patients who have been diagnosed with this disease and to provide their parents with more complete information regarding the cause of this disease. This research is being done because many unanswered questions remain regarding children with infantile hemangioma. There are very few medications to treat infants with hemangiomas.
详细描述
WHAT IS INVOLVED IN THE RESEARCH STUDY?
- Buccal smear (cheek cells) or small blood sample (4 mL or 1 teaspoon) from child being seen in the Dermatology clinic having infantile hemangioma or vascular anomaly
- Buccal smear (cheek cells) or small blood sample (4 mL or 1 teaspoon) from parents of child
If you and your child agree to be in this study, the following will happen:
- Informed consent and permission to use or disclose your/your child's health information for research purposes will be obtained by Dr. Drolet, the principal investigator, or her research team. You will receive a copy of this consent form.
- A buccal swab or blood sample will be obtained from you and your child; buccal sampling involves rubbing the inside of your cheek and removing cells to perform a genetic test called "Genomewide Association (GWA).
We expect you and your child to be involved in this study until you and your child have the genetic testing performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •No limit to age
- •Diagnosis of infantile hemangioma and/or vascular anomaly
- •Unaffected twin sibling
- •Each patient's authorized legal guardian must understand the nature of the study and must provide written informed consent. Each patient must also give assent to study participation.
- •Study Population
排除标准
- •Diagnosis other than infantile hemangioma or vascular anomaly
- •If the lesion has resolved and cannot be confirmed as a hemangioma by clinical exam
- •If the biologic parents are unwilling or unable to submit DNA samples the child will be excluded from the DNA study. Therefore, if DNA samples cannot be or are not obtained from both biologic parents, the child and family will be excluded from the study.
结局指标
主要结局
SNP
时间窗: 3 years
次要结局
未报告次要终点
研究者
Beth A Drolet, MD
Professor and Vice Chairman of Pediatric Dermatology
Medical College of Wisconsin