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临床试验/NCT07606469
NCT07606469尚未招募不适用

Neuronal Mechanisms of Human Cognition

University of Colorado, Boulder1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2026年6月15日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
30
试验地点
1

研究概览

简要总结

Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.

详细描述

The investigators will analyze recorded neural activity, eye movements, and behavioral responses from epilepsy patients undergoing intracranial monitoring with clinically-relevant microelectrodes in hippocampus that perform a decision-making task. The participants will perform 1 session of the task during their monitoring period. Behavioral responses will be fit to inference models to identify strategies subjects use, and neural recordings (neuronal firing and low frequency activity) will be correlated with task features by comparing results to those produced by randomized (bootstrapped) data. Neural activity and corresponding behavioral strategies for each participant will be used to refine theoretical recurrent neural network models of hippocampal engagement in multi-timescale inference.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Other

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Epilepsy patients undergoing intracranial electrode monitoring for uncontrolled seizures.
  • no lesions identified in the participants' brains
  • capable of giving consent

排除标准

  • seizure activity during task recording
  • electrodes in regions of interest are identified to be the seizure focus
  • task performance outside of the normal range as determined from online studies with healthy participants

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Tahra Eissa

Assistant Professor

University of Colorado, Denver

研究点 (1)

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