Perioperative Hemodynamic and Respiratory Changes During Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Combined With Cytoreductive Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- physiological parameter; systolic/diastolic blood pressure
研究概览
简要总结
Hyperthermic Intraperitoneal Chemotherapy (HIPEC) involves the intraoperative administration of heated chemotherapeutic agents into the abdominal cavity following cytoreductive surgery (CRS). The increasing use of CRS combined with HIPEC has introduced certain procedural and physiological considerations that distinguish it from other surgical interventions, posing unique challenges for researchers and clinicians alike.
Despite advancements in surgical and anesthetic techniques, this combined approach is frequently associated with significant hemodynamic instability, coagulation abnormalities, respiratory complications, and nutritional imbalances.
The study aims to contribute to the existing body of knowledge by examining the physiological alterations induced by HIPEC, thereby offering practical insights and guidance for investigators involved in the management and study of this complex therapeutic modality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥18 years old Patients planned to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
- •ASA II-III-IV physical class
排除标准
- •<18 years
- •Emergency cases
结局指标
主要结局
physiological parameter; systolic/diastolic blood pressure
时间窗: Intraoperatively
Systolic/diastolic blood pressure will be recorded in mmHg every 10 minutes.
physiological parameter; SpO2
时间窗: Intraoperatively
SpO2 will be recorded as percent every 10 minutes.
anesthesia device measurement parameter; EtCo2
时间窗: Intraoperatively
EtCo2 will be recorded every 10 minutes as mmHg.
anesthesia device measurement parameter; Pmax
时间窗: Intraoperatively
Pmax will be recorded as cmH2O every 10 minutes.
physiological parameter ; heart rate
时间窗: Intraoperatively
HIPEC is usually the application of chemotherapy that lasts between 45 and 90 minutes after the end of cytoreductive surgery. During HIPEC application (45-90 minutes), Heart rate: will be recorded every 10 minutes as beats / minute.
次要结局
- Preoperative data(24 hours before surgery)
- Postoperative data(24 hours after surgery)
研究者
Miray Gözde Özdemir
Anesthesiology and Reanimation specialist / Doctor
Ankara Etlik City Hospital