Effect of Sofosbuvir or Ledipasvir/Sofosbuvir Therapy on Liver Fibrosis in Japanese Patients with Hepatitis C Virus Infection - sofosbuvir

A total of 98.1% of (n=101/103) patients in genotype 1 cohort and 100% (n=16/16) in the genotype 2 cohort achieved SVR12. Based on per-protocol analysis, M2BPGi levels showed a significant decrease (-2.2 cut-off index [COI], P<.0001) at week 48 after treatment initiation. Forty-three patients showed a significant decrease in Fib-4 index (-1.2, P<.0001), and 44 patients showed improvement in LSM (-5.9 kPa, P<.0001).Achievement of SVR after antiviral therapy was associated with fibrosis regression.