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临床试验/NCT03867058
NCT03867058终止不适用

Tradeoff Between Spatial Resolution of Neural Excitation and Temporal Rate Processing

East Carolina University1 个研究点 分布在 1 个国家目标入组 53 人开始时间: 2019年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
终止
入组人数
53
试验地点
1
主要终点
Sensitivity to stimulation rate change at threshold

研究概览

简要总结

In this study, investigators will examine how temporal rate processing might be affected when the width of neural excitation narrows. The manipulation of neural excitation width will be achieved for example by changing electrode configurations or stimulating single versus multiple electrodes simultaneously. Investigators will then measure if the extent to which rate processing is affected by spatially restricted stimulation can predict a subject's overall speech recognition and predict also whether the subject is likely to benefit from a focused electrode configuration. Lastly, investigators will introduce and test a novel current focusing strategy where current focusing is applied in a channel specific manner and quantify if this intervention improves speech recognition. The primary endpoint of the study is speech recognition, and the secondary endpoint is psychophysical sensitivity to stimulation rate change.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
15 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Native speakers of English
  • Cochlear Nucleus cochlear implant users or Advanced Bionics users
  • Postlingually deafened
  • Has had device experience for at least one year
  • Can be child or adult at the time of enrollment

排除标准

  • 未提供

结局指标

主要结局

Sensitivity to stimulation rate change at threshold

时间窗: starting 6 months post award notice and will take up to 4 years to complete

Subjects' psychophysical detection thresholds will be measured as a function of the rate of stimulation delivered to selected electrodes and selected electrode configuration

Discrimination of stimulation rate

时间窗: starting 6 months post award notice and will take up to 4 years to complete

subjects' ability to discriminate stimulation rates will be measured as a function of base stimulation rates at selected electrodes and selected electrode configuration.

次要结局

  • Speech recognition(starting 6 months post award notice and will take up to 4 years to complete)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Heather Wright

professor

East Carolina University

研究点 (1)

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