Tradeoff Between Spatial Resolution of Neural Excitation and Temporal Rate Processing
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Sensitivity to stimulation rate change at threshold
研究概览
简要总结
In this study, investigators will examine how temporal rate processing might be affected when the width of neural excitation narrows. The manipulation of neural excitation width will be achieved for example by changing electrode configurations or stimulating single versus multiple electrodes simultaneously. Investigators will then measure if the extent to which rate processing is affected by spatially restricted stimulation can predict a subject's overall speech recognition and predict also whether the subject is likely to benefit from a focused electrode configuration. Lastly, investigators will introduce and test a novel current focusing strategy where current focusing is applied in a channel specific manner and quantify if this intervention improves speech recognition. The primary endpoint of the study is speech recognition, and the secondary endpoint is psychophysical sensitivity to stimulation rate change.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 —(Child, Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Native speakers of English
- •Cochlear Nucleus cochlear implant users or Advanced Bionics users
- •Postlingually deafened
- •Has had device experience for at least one year
- •Can be child or adult at the time of enrollment
排除标准
- 未提供
结局指标
主要结局
Sensitivity to stimulation rate change at threshold
时间窗: starting 6 months post award notice and will take up to 4 years to complete
Subjects' psychophysical detection thresholds will be measured as a function of the rate of stimulation delivered to selected electrodes and selected electrode configuration
Discrimination of stimulation rate
时间窗: starting 6 months post award notice and will take up to 4 years to complete
subjects' ability to discriminate stimulation rates will be measured as a function of base stimulation rates at selected electrodes and selected electrode configuration.
次要结局
- Speech recognition(starting 6 months post award notice and will take up to 4 years to complete)
研究者
Heather Wright
professor
East Carolina University
