Crop-Derived Bioactive Compounds for Improved Gut Health and Nutrition
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
研究概览
简要总结
A trial evaluating the systemic and ecological impact of zinc-biofortified maize consumption on cellular zinc status, inflammatory biomarkers, and gut microbiota composition in a cohort of Guatemalan mothers and children.
详细描述
This is a pilot study conducted among a subset of participants in a larger food aid intervention program using biofortified maize (N=499). This analysis focuses on a highly compliant cohort of 30 households (N=60 individuals) providing high-fidelity multi-omic data.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 24 Months 至 49 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Household Inclusion Criteria:
- •Reside in the target area (Chiquimula Department, Guatemala);
- •Participating in the World Vision (WV) nutrition program;
- •Families accustomed to consuming maize;
- •Interest to participate in an informative session;
- •Presence of at least one woman of reproductive age (18-49 years) and one index child (12-59 months);
- •Access to a mobile phone; (7) No concurrent participation in other nutrition or food aid programs.
排除标准
- •Women with problems understanding the study informed consent and the study survey;
- •Women with any acute or chronic disease that affected dietary intake or nutritional status;
- •Children with acute malnutrition 4.Children with any acute or chronic disease that affected dietary consumption or nutritional status;
- •Households that failed to adhere to the study protocol during the previous intervention period (e.g., sold the study maize or diverted it for animal feed).
研究组 & 干预措施
F3 Biofortified Maize
16 households (mothers and children) received zinc-biofortified maize seed (F3) for planting and maize consumption as part of their daily diet (Phase I). Due to implementation challenges (harvest failure due to drougth), the intervention was changed to delivery to zinc-biofortified maize grain for consumption (Phase II).
干预措施: F3 Biofortified Maize (Other)
Conventional Maize (Control)
14 households (mothers and children) planted regular maize (Phase I). Due to implementation challenges (harvest failure due to drougth), the intervention was changed to delivery of regular maize grain for consumption (Phase II).
干预措施: Conventional Maize (Other)
研究者
Manolo Mazariegos
Head, Dept. Nutrition and Micronutrients
Institute of Nutrition of Central America and Panama