Hypoxia, Lung Function and Diffusion Capacity After Abdominal Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- Diffusion capacity for carbon monoxide (DLCO)
研究概览
简要总结
The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery.
Inclusion: Patients undergoing surgery for abdominal surgery
Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies.
Investigation: The day before surgery and the day after surgery
Primary outcome measures:
- Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide.
- PaO2, PaCO2 and oxygen saturation (blood gas)
详细描述
Postoperative hypoxia complicates 30% - 50% of abdominal surgeries. People at particular risk for postoperative pulmonary complications including severe hypoxia are those who undergo abdominal surgery, emergency surgery or have a respiratory failure due to chronic lung disease including obstructive sleep apnea. The cause of postoperative restrictive lung function and hypoxia is unknown. Previous studies report that PaO2 decreases by an average of 2 kPa after abdominal surgery, while PaCO2 is unchanged and vital capacity decreases by 35%.
The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery.
Design: Prospective cohort study
Inclusion: Patients undergoing surgery for abdominal surgery
Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (18 years old and older) scheduled for surgery in the abdomen at department of Surgery, Urology and Gynecologi, Umeå University hospital.
- •Must be able to perform a lung function test
排除标准
- •Dementia or severe cognitive impairment
结局指标
主要结局
Diffusion capacity for carbon monoxide (DLCO)
时间窗: Change from baseline (the day before surgery) to postoperative day 1 or 2
Change in DLCO
次要结局
- Arterial PO2(Change from baseline (the day before surgery) to postoperative day 1 or 2)
- Vital capacity (VC)(Change from baseline (the day before surgery) to postoperative day 1 or 2)
- Arterial PCO2(Change from baseline (the day before surgery) to postoperative day 1 or 2)
- Forced expiratory volume (FEV1)(Change from baseline (the day before surgery) to postoperative day 1 or 2)