Blood Pressure Responses to Isometric Blood Flow Restriction Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Brachial artery diameter evaluated by an ultrasound machine
研究概览
简要总结
The goal of this interventional study is to evaluate the acute impact of isometric blood flow restriction (BFR) exercise on blood pressure and other cardiovascular functions in healthy young adult volunteers. The main question it aims to answer is:
The investigators hypothesize that isometric BFR exercise with a wide-rigid cuff would lead to greater blood pressure and other cardiovascular responses and that these cardiovascular responses would be greater under isometric BFR exercise with narrow-elastic bands compared with the control condition (no cuff).
Participants will perform isometric exercises in 3 laboratory visits with different exercise conditions) no cuff control 2) BFR with wide-rigid cuff 3) BFR with narrow-elastic band.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- Apparently healthy young adults aged between 18 - 40 years old and signed the informed consent.
排除标准
- •Abnormal clotting times
- •Acid-base imbalance/acidosis
- •Arterial calcification
- •Atherosclerotic vessels
- •Cardiopulmonary conditions
- •Dialysis/central venous access
- •General/local infection
- •High intracranial pressure
- •Hip, pelvis, or femur fracture
- •History of venous thromboembolism
- •Hypertension
- •Immobility for greater than 48 hours in the past month
- •Immobilizing cast
- •Implanted medical device
- •Lymphectomies
- •Open fracture
- •Open or unhealed soft tissue injuries
- •Paralysis
- •Peripheral vascular disease
- •Pregnancy/postpartum
- •Prior revascularization
- •Renal compromise
- •Severe crush injuries
- •Sickle cell trait/anemia
- •Skin grafts
- •Temporary nerve damage
- •Thrombophilia
- •Tumor/cancer
- •Varicose veins
- •Vascular grafting
研究组 & 干预措施
Isometric exercise with narrow-elastic BFR band
干预措施: Isometric handgrip exercise with a narrow-elastic band (Behavioral)
Isometric exercise with wide-rigid BFR cuff
干预措施: Isometric handgrip exercise with a wide-rigid cuff (Behavioral)
Isometric exercise without BFR cuff (control)
干预措施: Isometric handgrip exercise (Behavioral)
结局指标
主要结局
Brachial artery diameter evaluated by an ultrasound machine
时间窗: Before and 20 minutes after exercise
Brachial artery diameter will be measured by an ultrasound machine to calculate flow-mediated dilation (FMD)
Heart rate
时间窗: 20 minutes
Monitor heart rate continuously before, during, and after exercise
Systolic blood pressure and diastolic blood pressure
时间窗: 20 minutes
Beat-by-beat (both systolic and diastolic blood pressure) blood pressure before, during, and after exercise
次要结局
未报告次要终点
研究者
Hirofumi Tanaka
Professor
University of Texas at Austin