Assessment of Hemostatic Profile in Patients With Mild to Advanced Liver Cirrhosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- Aggregation of platelets
研究概览
简要总结
Our study included both in- and outpatients suffering from liver cirrhosis attending the out- and inpatient care of the department of hepatology. Demographic and biochemical data as well as medical history including cause of liver cirrhosis, end stage kidney failure and medication with anticoagulants were recorded. To assess the hemostatic profile, platelet function was analyzed by multiple electrode aggregometry (MEA) using Multiplate (ADP-, ASPI- and TRAP-test) and thrombelastometry using ROTEM (EXTEM, INTEM, FIBTEM).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •liver cirrhosis
- •age of ≥ 18 years
- •platelet count of at least 70 / nl
排除标准
- •transfusion of platelet concentrate three weeks prior to inclusion
- •pregnancy
- •age < 18 years
- •missing informed consent
结局指标
主要结局
Aggregation of platelets
时间窗: Venous blood was collected via a cannula inserted into a cubital vein. Platelet function was measured by MEA using the Multiplate analyzer 15min after blood draw and after activation with commercially available standard reagents
AUC of impedance aggregometry using multiple electrode aggregometry
次要结局
- Viscoelastic measurements(Venous blood was collected via a cannula inserted into a cubital vein. Thrombelastometric assays were performed 15min after blood draw.)
研究者
Elisabeth H. Adam
Division Chief of Critical Care
Goethe University