NCT04489472招募中不适用
The Effect of a Dietary Supplement Rich in Nitric Oxide in Patients Diagnosed With Primary Ciliary Dyskinesia.
The University of Texas Health Science Center, Houston2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2019年7月31日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in nasal FeNO as measured by using the NIOX MINO® Airway Inflammation Monitor
研究概览
简要总结
The purpose of this study is to determine the effect of a dietary supplement rich in nitric oxide (NO) on nasal nitric oxide and fractional exhaled nitric oxide (FeNO),on ciliary beat frequency assessed by high-speed digital video microscopy and on lung function assessed by spirometry in normal patients and patients with Primary ciliary dyskinesia (PCD).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 4 Years 至 99 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Experimental group:
- •PCD patients
- •Control Group:
- •patients with no known chronic lung disease
- •18 years to 99 years
排除标准
- •(both PCD patients and control group):
- •any other pulmonary co-morbidities and diseases entities like cystic fibrosis, nasal sinus surgery, nasal sinus hypoplasia/aplasia, deviated nasal septum, nasal polyps and with upper respiratory tract infection
- •patients allergic to beet
- •a known prolonged bleeding disorder.
结局指标
主要结局
Change in nasal FeNO as measured by using the NIOX MINO® Airway Inflammation Monitor
时间窗: Baseline,after beet juice consumption(2 hours after consumption)
Change in nasal NO as measured by a chemiluminescence analyzer
时间窗: Baseline,after beet juice consumption( 2 hours after consumption)
次要结局
- Change in ciliary beat frequency as measured using high-speed video-microscopy (HSVM)(after beet juice consumption(2 hours after consumption))
- Change in lung function as measured by spirometry(Baseline,after beet juice consumption(2 hours after consumption))
研究者
Ricardo A. Mosquera
Associate Professor
The University of Texas Health Science Center, Houston
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLDArgininosuccinate Lyase DeficiencyUrea Cycle Disorders, InbornUrea Cycle DisorderArgininosuccinic AciduriaNCT03064048Baylor College of Medicine16
Unknown
不适用
Dietary Nitrate on Plasma Nitrate Levels for Nasopharyngeal Carcinoma PatientsNasopharyngeal CarcinomaNCT02044562Capital Medical University20
已完成
不适用
Nitric Oxide Supplementation in Argininosuccinic AciduriaArgininosuccinic AciduriaArgininosuccinate Lyase DeficiencyUrea Cycle DisordersNCT02252770Baylor College of Medicine12
已完成
2 期
Effect of Beetroot Juice on Coronary Blood Flow and Walking Performance in PADPeripheral Arterial DiseaseNCT02553733David N. Proctor, PhD11
已完成
不适用
Dietary Nitrate and Physiological AgingAgingNCT02593305Darren P Casey23