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临床试验/NCT03083080
NCT03083080Unknown不适用

Ultrasound-guided Peripheral Nerve Block for Non-intubated Uniportal Video-assisted Thoracoscopic Surgery

Taipei Medical University WanFang Hospital0 个研究点目标入组 30 人开始时间: 2017年3月27日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
入组人数
30
主要终点
Numerical rating scale intraoperatively

研究概览

简要总结

Traditionally, video-assisted thoracic surgery is performed under general anesthesia with double-lumen endotracheal tube. However, the complications associated with this large tube as well as inhalation anesthetics are frequently reported. Therefore, currently there is a trend toward non-intubated anesthesia methods for video-assisted thoracic surgery, which includes thoracic epidural block, peripheral nerve block, local anesthesia, local combined with peripheral nerve block, etc. Thoracic epidural block demands a high technique, but still risks catastrophic neurological complications in case of accidental dural puncture. Local anesthesia, perhaps more straightforward, however may need supplemental analgesia during incision, which will inevitably interrupt surgery and negatively affect the patients. This study aims to apply ultrasound guidance during local anesthetic injection for local anesthesia-based video assisted thoracic surgery, which helps inject the local anesthetic into the key intercostal nerve plane to provide more specific and precise blockade, thus avoiding the chance of blind injection. At the same time, ultrasound guidance has the potential to reduce the risk of systemic toxicity, prolong the duration of analgesia postoperatively, and facilitates postoperative recovery.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
20 Years 至 79 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adults younger than 80 years old and weighing between 50-90 kg are scheduled for one-port video assisted thoracic surgery .

排除标准

  • Anticipated difficult airway
  • Obvious coagulation abnormality
  • Psychiatric patients or drug addiction
  • Emergency operation or patients with a full stomach
  • Difficulty in language expression
  • Allergic to local anesthetic, morphine, or NSAID
  • BMI > 35
  • Pregnancy
  • Respiratory insufficiency
  • Severe pleural adhesion
  • Need for pleurodesis
  • Refuse patient-controlled analgesia
  • Patients with a pacemaker
  • Severe liver dysfunction (serum albumin<25g/l or Child-Pugh score≧10)
  • Severe kidney dysfunction (creatinine clearance<30ml/min)
  • Inflammatory bowel disease
  • Congestive heart failure (NYHA II-IV)
  • Confirmed ischemic heart disease, peripheral arterial disease and/or cerebral vascular disease
  • Patients with a high intra-ocular pressure (e.g. glaucoma)
  • Neurological symptoms over the ipsilateral upper part of the body

研究组 & 干预措施

VATS block (ropivacaine + epinephrine)

Experimental

VATS block is the peripheral nerve block for video-assisted thoracic surgery, whose injection is administered at the site of chest wall incision.

干预措施: VATS (Procedure)

VATS block (ropivacaine + epinephrine)

Experimental

VATS block is the peripheral nerve block for video-assisted thoracic surgery, whose injection is administered at the site of chest wall incision.

干预措施: Ropivacaine (Drug)

VATS block (ropivacaine + epinephrine)

Experimental

VATS block is the peripheral nerve block for video-assisted thoracic surgery, whose injection is administered at the site of chest wall incision.

干预措施: Epinephrine (Drug)

结局指标

主要结局

Numerical rating scale intraoperatively

时间窗: During chest wall incision

Self-reporting pain intensity, pain site, and analgesic dosage during surgery

TIme to lose skin sensation (light touch and thermal) over the injection site

时间窗: Up to 30 mins after ropivacaine injection

Skin sensation will be tested every 5 minutes after ropivacaine injection until loss of both sensation (readiness for skin incision)

次要结局

  • Common characteristics of ultrasound anatomy by analyzing video clips(Three time points (upon obtaining informed consent, prior to injection and during injection))
  • Ropivacaine concentration at different time points after injection(Up to 120 mins following injection)
  • Numerical rating scale postoperatively(Up to 72 hours following surgery)

研究者

申办方类型
Other
责任方
Sponsor

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