Myoinositol Therapy May Adjust The Metabolic Deregulation in Infertile Polycystic Ovarian Syndrome (PCOS) Women Through Modulation of The TyG Index-BMI: A Comparative Study Versus Metformin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- Success Rate of Treatment Regimens in Restoring Menstrual Regularity and/or Achieving Pregnancy
研究概览
简要总结
The study aimed to assess how a 6-month insulin sensitizer therapy impacts insulin resistance, glucose tolerance, and hormonal levels in women with PCOS. Researchers evaluated 156 PCOS patients, measuring their BMI, HOMA-IR (for insulin resistance), TyG index, TyG index-BMI, and total testosterone. Participants were divided into two groups, receiving either metformin or a myoinositol/d-chiro-inositol combination for six months, after which all parameters were re-evaluated to determine the percentage of change.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 23 Years 至 47 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients presenting manifestations suggestive of having PCOS;
- •Patients were free of exclusion criteria.
排除标准
- •Patients who were maintained on a diet regimen, or/and regular exercise;
- •Patients who were on medical therapy of PCOS, antidiabetic or/and antihypertensive therapy;
- •Patients who underwent laparoscopic drilling;
- •Patients with dyslipidemia, hereditary lipoprotein disorders:
- •Patients with chronic liver or kidney diseases.
研究组 & 干预措施
Myoinositol Group
Patients presenting manifestations suggestive of having PCOS were evaluated for enrollment in the study, and took the tablets containing myoinositol/d-chiro-inositol combination (MYO/DCI) in 40:1 ratio
干预措施: Myoinositol (Drug)
Metformin Group
Patients presenting manifestations suggestive of having PCOS were evaluated for enrollment in the study, and took metformin (MET) hydrochloride 500 mg
干预措施: Metformin Hydrochloride 500 MG (Drug)
结局指标
主要结局
Success Rate of Treatment Regimens in Restoring Menstrual Regularity and/or Achieving Pregnancy
时间窗: 6~7 Months
The proportion of patients who regained a regular menstrual pattern and/or achieved pregnancy during the study, reflecting the effectiveness of the administered treatment regimens.
次要结局
未报告次要终点
研究者
Basma Sakr
Assistant Professor of Obstetrics & Gynecology, Faculty of Medicine, Benha University
Benha University