THE HEALTHY COOKIE ENERGY STUDY: Understanding How Healthy Cookies Affect Mitochondrial Biology
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Changes in cardiolipin species
研究概览
简要总结
The proposed research is an intervention and feasibility pilot trial designed to determine if short-term consumption of healthy cookies made with an oil rich in linoleic acid can influence mitochondria biology in white blood cells and muscle. The hypothesis of the study is that consuming 1 healthy cookie rich in linoleic acid each day for two weeks will improve mitochondrial biology in white blood cells and muscle.
详细描述
Linoleic acid has many health benefits including altering body composition and energy metabolism, possibly through its impact on cardiolipin and mitochondria.
The investigators plan to test the central hypothesis and accomplish the overall objective of this research by pursuing the following four specific aims
Aim 1) To assess muscle biopsy yield with a micro biopsy needle
Aim 2) To determine the amount of peripheral blood mononuclear cells (PBMC) and muscle needed to measure mitochondria function
Aim 3) To assess the feasibility of measuring mitochondria function on fresh PBMC and muscle samples
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Nonsmoker
排除标准
- •Allergy/intolerance to lidocaine
- •Gastrointestinal diseases or disorders (including pancreatic) or gastric bypass surgery
- •Food Allergy or Intolerance
- •Any dietary restriction where consumption of these healthy cookies or any ingredient would be contraindicated
- •Use of medications where consuming the healthy cookies would be contraindicated
- •Pregnancy
- •Use of anticoagulant, antiplatelet, or other blood thinner medications
研究组 & 干预措施
Healthy Cookie Group
All participants in the study
干预措施: High Linoleic Acid Healthy Cookies (Other)
结局指标
主要结局
Changes in cardiolipin species
时间窗: Week 0 to week 2
Cardiolipin species in peripheral blood mononuclear cells and skeletal muscle
Changes in mitochondria function
时间窗: Week 0 to Week 2
Mitochondria function measured in peripheral blood mononuclear cells and skeletal muscle
Correlation of mitochondrial biology in blood and skeletal muscle
时间窗: Week 0 and week 2
Correlation of mitochondria function and cardiolipin species in peripheral blood mononuclear cells and skeletal muscle
次要结局
- Changes in fasting fatty acid levels(Week 0 to week 2)
- Correlation of fatty acids with mitochondrial function and cardiolipin species(Week 0 and week 2)
- Correlation of cardiolipin with global sleep quality score, Cambridge physical activity index and dietary intake of omega-3 fats(Week 0 and week 2)
- Correlation of cardiolipin with body mass index, sagittal diameter (abdominal thickness), walking speed and grip strength(Week 0 and week 2)
研究者
Martha Belury
Associate Professor
Ohio State University