Evaluation of Placental Transfusion Techniques in of Prematurity Related Complications and Hematological Profile
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Hemoglobin level
研究概览
简要总结
The objective of this study is to evaluate the general course and prognosis associated with different methods of placental transfusion (Intact umbilical cord milking, cut- umbilical cord milking and delayed cord clamping) in premature neonates over the first days of life
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 1 Minute 至 2 Minutes（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion Criteria:
- •Premature neonates ≤ 32 weeks gestational age regardless birth weight
- •patients should be admitted to neonatal intensive care unit in the first day of life of life
排除标准
- •Exclusion Criteria:
- •Patient with any of the following will be excluded:
- •Major congenital anomalies (complex cyanotic heart disease, major central nervous system anomalies).
- •Evidence of head trauma causing major intracranial hemorrhage.
- •placental abnormalities like : abruptions, placenta previa or retroplacental hematoma.
- •Cord accident, or avulsion at the time of delivery.
- •Refusal to perform the intervention by the obstetrician
研究组 & 干预措施
The procedure of Delayed Cord Clamping (DCC):
Infants placed on the maternal abdomen or at the introitus below the level of placenta and waiting at least 30- to 60-second before clamping the cord.
干预措施: Delayed cord clamping (Procedure)
Control group:
patients will not receive any of the methods of placental transfusions
The procedure of intact umbilical cord milking (I-UCM)
Umbilical cord milking will be performed by holding the newborn at or
∼20 cm below the level of the placenta. The cord will be pinched between 2 fingers as close to the placenta as possible and milked toward the infant over a 2-second duration. The cord will then be released and allowed to refill with blood for a brief 1- to 2-second pause between each milking motion. This will be repeated for 2-4 times. After completion, the cord will be clamped, and the neonate will be handed to the resuscitation team.
干预措施: intact umbilical milking (Procedure)
The procedure of Cut-umbilical cord milking(C-UCM):
Another technique, used more often in Asia, involves clamping and cutting a long segment of the umbilical cord immediately at birth and passing the baby and the long cord to the pediatric provider, called C-UCM untwists the cord and milks the entire contents into the baby. Milking the cord 2-3 times before clamping may produce a similar placental transfusion as C-UCM
干预措施: cut umbilical milking (Procedure)
结局指标
主要结局
Hemoglobin level
时间窗: on admission (In first day after birth),as well as, at end of first , second and third weeks of lives
hemoglobin level will be measured in gram/dl
次要结局
未报告次要终点
研究者
Marwa Mohamed Farag
Assistant professor of Pediatrics
Alexandria University