NCT03216239已完成不适用
Does Colectomy Predispose to Small Intestinal Bacterial (SIBO) and Fungal Overgrowth (SIFO)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- Prevalence of SIBO/SIFO
研究概览
简要总结
After subtotal colectomy, 40% of patients report abdominal pain, gas and diarrhea, and poor quality of life; whose etiology is unknown. The investigators determined whether small intestinal bacterial (SIBO or fungal overgrowth SIFO) could cause these sympotoms (> 1 year).
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who were referred to a specialist motility center over 4 year period with:
- •Unexplained gastrointestinal symptoms such as gas, bloating, belching, diarrhea, and abdominal discomfort
- •history of colectomy
- •patients with no history of colectomy
- •patients included who had normal: upper endoscopy, colonoscopy, computerized abdominal tomography scan, and normal hematology, biochemical profiles, tissue transglutaminase antibody, thyroid stimulating hormone, and normal right upper quadrant ultrasound scan.
- •patients with glucose breath test and/or duodenal aspirate
排除标准
- •patients with upper gut or small bowel surgery
- •Patients who were hospitalized or with serious cardiac or pulmonary or neurologic comorbidities
- •Patients with intestinal strictures or known intestinal motility disorders such as scleroderma or pseudo-obstruction syndrome
结局指标
主要结局
Prevalence of SIBO/SIFO
时间窗: 4-5 years
Patients with unexplained GI symptoms following colectomy and to compare this with a control group of patients with similar symptoms but without previous colectomy.
次要结局
- Response to treatment with antibiotics and antifungals(4-5 years)
研究者
Satish Rao
Professor of Medicine, Director of Neurogastroenterology/Motility
Augusta University
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