The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 110
- 试验地点
- 2
- 主要终点
- Change in maximal voluntary contraction force
研究概览
简要总结
In the present project, the investigators aim at proposing innovative ways of investigating spinal motoneuron hyperexcitability to counteract the associated impairments by using wide pulse high frequency neuromuscular electrical stimulation (WPHF NMES) in various populations. The investigators will use WPHF NMES contractions as a model to gain insights into the mechanisms underlying muscle cramps, restless legs syndrome or stroke-induced spasticity as there is evidence that they share common underlying mechanisms. The investigators will then use WPHF NMES as a training modality to improve plantar flexor neuromuscular function in stroke patients by taking advantage of their motoneuronal hyperexcitability.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Change in maximal voluntary contraction force
时间窗: through study completion, an average of 8 weeks
Change from baseline maximal voluntary contraction force after the six-week training period in stroke patients
Estimates of persistent inward current (Delta F assessed with high-density surface electromyography and/ or the torque measured during vibration after the last bout of NMES)
时间窗: through study completion, an average of 8 weeks
comparison of estimates of persistent inward current strength in plantar flexor muscles between patients (prone to cramps or restless legs) and healthy volunteers
Change in NMES-evoked force
时间窗: through study completion, an average of 8 weeks
Change from baseline NMES-evoked force after the six-week training period
Change in estimates of persistent inward current (Delta F assessed with high-density surface electromyography and/ or the torque measured during vibration after the last bout of NMES)
时间窗: through study completion, an average of 8 weeks
Change from baseline estimates of persistent inward current after the six-week training period in stroke patients
NMES-evoked force
时间窗: through study completion, an average of 2 weeks
Comparison of NMES-evoked force in plantar flexor muscles between patients (prone to cramps or restless legs) and healthy volunteers
次要结局
- 10-m walking test (s)(through study completion, an average of 8 weeks)
- Change in spinal excitability in stroke patients(through study completion, an average of 8 weeks)
- Spinal excitability(through study completion, an average of 2 weeks)
- Change in voluntary activation level and contractile properties of the plantar flexor muscles(through study completion, an average of 8 weeks)
- voluntary activation level and contractile properties of the plantar flexor muscles(through study completion, an average of 2 weeks)
- 6-min walking test (m)(through study completion, an average of 8 weeks)
- time up and go test (s)(through study completion, an average of 8 weeks)
- change in spasticity at the ankle joint level for stroke patients(through study completion, an average of 8 weeks)
- Cramp threshold frequency (CTF) for cramp-prone individuals(through study completion, an average of 2 weeks)
研究者
Nicolas Place
Professor
University of Lausanne