NCT01666067已完成4 期
Vascular and Metabolic Effects of Vytorin vs Simvastatin
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 204
- 试验地点
- 1
- 主要终点
- flow-mediated dilation
研究概览
简要总结
The investigators hypothesize that vytorin will improve insulin resistance compared with simvastatin
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hypercholesterolemic patients (LDL cholesterol levels>100 mg/dl)
排除标准
- •overt liver disease, chronic renal failure, hypothyroidism, myopathy, uncontrolled diabetes (HbA1c > 9%), severe hypertension, stroke, acute coronary events, coronary revascularization within the preceding 3 months, or alcohol abuse
研究组 & 干预措施
placebo
Active Comparator
placebo
干预措施: placebo (Drug)
vytorin
Active Comparator
vytorin
干预措施: vytorin (Drug)
simvastatin
Active Comparator
simvastatin
干预措施: simvastatin (Drug)
结局指标
主要结局
flow-mediated dilation
时间窗: 8 weeks of treatment
次要结局
- insulin resistance(8 weeks of treatment)
研究者
Kwang Kon Koh
professor
Gachon University Gil Medical Center
研究点 (1)
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