Frequency of Thyroid Disorders in Pediatric Patients With Autoimmune Hepatitis at Assiut University Children's Hospital
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 32
- 主要终点
- Frequency of thyroid disorders
研究概览
简要总结
This cross-sectional study aims to determine the frequency and spectrum of thyroid disorders among children with autoimmune hepatitis attending Assiut University Children's Hospital.
详细描述
Autoimmune hepatitis is frequently associated with other autoimmune disorders, particularly autoimmune thyroid diseases. Thyroid dysfunction in children may remain asymptomatic yet affect growth and development.
This observational study will include children less than 18 years diagnosed with autoimmune hepatitis according to the Revised International Autoimmune Hepatitis Group (IAIHG) scoring system. All participants will undergo thyroid function tests (TSH, FT3, FT4), thyroid autoantibodies (anti-TPO, anti-Tg), and thyroid ultrasonography.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- — 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age less than 18 years
- •Diagnosis of autoimmune hepatitis according to the Revised International Autoimmune Hepatitis Group (IAIHG) scoring system
- •Written informed consent from parents or legal guardians
排除标准
- •- Previously diagnosed thyroid disorders before the diagnosis of autoimmune hepatitis
- •Medications known to interfere with thyroid function tests (other than corticosteroids or immunosuppressive therapy for AIH)
- •Chronic systemic diseases known to affect thyroid function independently of AIH
- •Other autoimmune disorders (celiac disease, diabetes, inflammatory bowel disease)
- •Refusal to participate
研究组 & 干预措施
Single cohort: Children with autoimmune hepatitis
Children less than 18 years with autoimmune hepatitis who will undergo thyroid function tests, thyroid autoantibodies, and thyroid ultrasonography.
结局指标
主要结局
Frequency of thyroid disorders
时间窗: Baseline
Number of participants with autoimmune hepatitis who have any thyroid disorder including overt or subclinical hypothyroidism, hyperthyroidism, or autoimmune thyroiditis based on thyroid function tests, autoantibodies, and ultrasonography
次要结局
- Serum free T4 level(Baseline)
- Pattern of thyroid disorders(Baseline)
- Thyroid autoantibody positivity(Baseline)
- Thyroid ultrasonographic abnormalities(Baseline)
- Serum TSH level(Baseline)
- Serum free T3 level(Baseline)
研究者
Arwa Alaaeldin Mohamed Ahmed
Resident Physician
Assiut University