Domain-general and Domain-specific Contributions to the Development of Numerical Cognition
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 58
- 试验地点
- 2
- 主要终点
- BOLD response
研究概览
简要总结
Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention. Recorded fMRI.
详细描述
Using T2*-weighted eip imaging, we measured BOLD response in two cohorts of healthy children while they were doing different cognitive tasks in the scanner. These tasks included solving non-symbolic (i.e. sets of elements) and symbolic (i.e. Arabic digits) addition and subtraction problems, a color control task, an attentional task measuring different facets of spatial attention, and a task measuring inhibition. We also recorded a high-resolution anatomical scan of the brain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 5 Years 至 7 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •school enrollment
- •French as mother tongue
- •right-handed
- •normal medical, neurological and neuroradiological examinations - parents affiliated to a social security scheme
排除标准
- •not within age range
- •monocygotic twins
- •- contraindications to an MRI examination (neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic ocular or cerebral foreign bodies close to nerve structures, metal prostheses, patient agitation: uncooperative or agitated patients, claustrophobic subjects, ventriculoperitoneal neurosurgical shunt valves, dental apparatus, etc.).
- •sudden onset of cognitive problems that could indicate a stroke; a history of head trauma with loss of consciousness lasting more than 1 hour, or encephalitis; - a chronic neurological, psychiatric, endocrine, hepatic or infectious condition
- •a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrinological or immunological disorders, cancer); - medication likely to interfere with brain imaging measurements
- •color blindness or uncorrected visual disorders
- •inability to take part in the study for geographical or psychiatric reasons
- •presence of pervasive developmental and/or acquisition disorders identified by parents or legal guardians and/or teachers
- •cerebral palsy
- •impaired fine motor skills
- •parents or legal guardians not affiliated to a social security scheme
- •unaccompanied by parent(s) or legal guardian(s) during visits.
- •tattoo not compatible with MRI
- •children and parents under legal protection
结局指标
主要结局
BOLD response
时间窗: during fMRI session
changes of BOLD response in experimental conditions
次要结局
未报告次要终点